Semaglutide
March 21, 2024
CJC-1295 DAC
CJC-1295 is a synthetic analogue of growth hormone releasing hormone (GHRH) that increases plasma levels of growth hormone and insulin-like growth factor 1 (IGF-1), it plays a vital role in developing muscle mass, increasing fat loss, and efficient synthesis of protein in the body. DAC is an additive moiety that prolongs the plasma half-life of CJC-1295.
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CJC-1295 Overview
CJC-1295 Versus CJC-1295 DAC
CJC-1295 is a modified version of the first 29 amino acids of GHRH, which means it is chemically similar to other GHRH analogues, like Sermorelin. It is most similar to modified GRF (1-29), but the two peptides are not identical. A great deal of confusion arises because of the similarities between these peptides and because CJC-1295 was originally created with an added chemical compound called the drug affinity complex (DAC).
DAC is added to the molecule, with the help of a lysine linker, to protect the peptide while it circulates in the blood stream. By allowing peptides to bind to the common blood protein albumin, DAC helps to ensure that the half-life of CJC-1295 is much longer than similar molecules like GRF (1-29).
Source: Oxford Academic
Originally, ConjuChem Biotechnologies, the developer of DAC, referred to the molecule containing DAC as simply CJC-1295. Confusion arose, however, because the peptide was also being offered without DAC. To avoid confusion, CJC-1295 that contains DAC is called CJC-1295-DAC and when it does not contain DAC it is referred to as CJC-1295 or CJC-1295-no DAC.
CJC-1295 Summary
CJC-1295 is a growth hormone secretagogue designed to have a long plasma half-life and to preserve the physiologic patterns inherent in the GH axis. On both accounts, the molecule has been a success. CJC-1295 has experienced limited interest in research settings due to the advent of a number of similar molecules and because of the proprietary nature of the molecule’s structure. Now that CJC-1295 can be manufactured at will, there is likely to be renewed interest in its properties, particularly as they apply to the increasingly frustrating problem of human infertility.
CJC-1295 exhibits moderate side effects, low oral and excellent subcutaneous bioavailability in mice. Per kg dosage in mice does not scale to humans. CJC-1295 for sale at Peptide Sciences is limited to educational and scientific research only, not for human consumption. Only buy CJC-1295 if you are a licensed researcher.
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